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OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

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Dual Therapy Stent

Netherlands Made

Stainless Steel 316L

CD34 antibodies

Bioabsorbable Polymer

Sirolimus Drug

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Combo Plus Dual Therapy Stent

COMBO Plus is more than just a drug-eluting stent (DES). It is a combination of traditional DES components with the addition of a biological coating.

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

Function of the Biological Coating

CD34 antibodies are immobilized on the surface of the stent and capture circulating endothelial progenitor cells (EPCs). The captured EPCs are triggered by sheer stress from the circulating blood and other cell signals to differentiate and mature into endothelial cells. COMBO Plus is the only stent with a biological coating that actively repairs the vessel morphology.

  

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

Sirolimus Release from a Bioabsorbable Polymer

The proprietary bioabsorbable polymer is coated on the abluminal side of the stent, allowing for directional drug release in 30 days and polymer absorption in 90 days. 

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

Dual Helix Stent Design

COMBO’s dual helix design is engineered for:

  •   Excellent radial strength
  •   Large side branch access
  •   Natural conformability

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

Key clinical findings

Unique 24-Month Neointimal Regression

A mechanistic study demonstrated that repeat OCT follow-up in the same patients showed a significant decrease in neointimal thickness and volume at 24-month compared to 9-month follow-up, indicative of neointimal maturation and stability. 

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

Low Event Rates demonstrate Safe Results

Studies have consistently shown low event rates. In the REMEDEE Registry (N=1000), 1-year results in an all comers' population showed effectiveness with low target lesion revascularization, and safety with low rates of cardiac death, myocardial infarction and stent thrombosis. 

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

Technical Specifications

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent

 

OrbusNeich Medical B.V - Combo Plus Dual Therapy Stent



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